Depology Peptide Complex

If you buy something through my links, I may earn an affiliate commission, at no cost to you. For more information, read the full disclosure here.

This post is sponsored by the brand, but the opinions I share are unbiased. Read the review disclosure for more information.

9.4Expert Score
Depology Peptide Complex 10% Serum
The Depology Peptide Complex 10% Serum formulated with Argireline™ Peptide is a solid option for individuals looking to address signs of aging and boost skin hydration, offering visible results and a promising addition to skincare regimens.
  • Lightweight, non-sticky, and non-greasy formula
  • Delivers short-term results as well as long-term results
  • Hydrates the skin on top of plumping effects
  • Great for all skin types, even sensitive skin
  • It may be expensive for some

I’ve been on a skincare journey lately, guys. My latest obsession? The Depology Peptide Complex 10% Serum formulated with Argireline™ Peptide. I’ve got to tell you, my first impressions are very positive!

Now, if your skincare knowledge is a work in progress, let’s take a quick detour to understand what peptides are all about.

Peptides are basically the building blocks of proteins needed by our skin, like collagen and elastin. They’re essential for maintaining that plumpness and firmness we all desire (and frankly deserve).

What caught my eye with this serum is its whopping 10% peptide complex, which means it’s packed with these youth-boosting ingredients.

In this article, we’ll dive deeper into how this serum worked on my skin. We’ll chat about everything from its texture to its performance so you can decide whether it’s worth adding to your own routine! So buckle up, and let’s get glowing together!

Overview Of The Depology Peptide Complex Serum

The Depology Argireline™ Peptide Serum is a serum formulated with Argireline™ peptide to prevent muscle movement that leads to wrinkle formation.

This serum also delivers notable wrinkle-reducing and preventive benefits, which help to combat fine lines and promote moisture levels in the skin.

​Apply this Peptide Complex Serum after cleansing and toning the skin every morning and night. This peptide serum works well layered in conjunction with the use of their Matrixyl 3000 Serum.

  • Reduce the appearance of fine lines and wrinkles;
  • Deeply moisturize dry and dull skin;
  • Prevent further signs of aging;
  • Easy to combine with any regimen. 

What Is Argireline™

Argireline™ is just a trade name for the peptide acetyl hexapeptide-3 (aka acetyl hexapeptide-8). Peptides are short sequences of amino acids that serve as the foundation for proteins such as collagen and elastin, making them crucial for healthy, young skin.

Some of the benefits of Argireline™ are: relaxes facial muscles, resulting in a reduction of lines, wrinkles, and even sagging skin. It has also been found to improve skin hydration, suppleness, and firmness.

Argireline™ has been called a “safe alternative” to Botulium Toxin, which requires a doctor’s visit for application. Injectables are typically administered by a trained doctor and can cost anywhere from $500 to $2000 for a single treatment.

This can add up to thousands of dollars if you need multiple injections over time. Depology Peptide Complex Anti-Wrinkle Serum comprises the key peptide, which is Argireline™ solution, that works by relaxing facial muscles responsible for creating wrinkles and lines.

How To Use

  • Preparation: Thoroughly cleanse and tone the skin.
  • Application: Apply a few drops of serum onto your palm and gently massage your face. Make sure to apply generously to areas where age lines form easily, such as the forehead and around the eyes.
  • After: After applying the Argireline™ serum, follow with the Matrixyl 3000 Serum for best results. After that, apply a moisturizer and sunscreen if applied in the morning.

Things To Consider

The Peptide Complex Anti-Wrinkle Serum is cruelty-free and alcohol-free.


Water, Isopentyldiol, 1,2-Hexanediol, Panthenol, Hydroxyethyl Urea, Butylene Glycol, Propanediol, Caprylyl Glycol, Glycerin, Sodium Hyaluronate, Ficus Carica (Fig) Fruit Extract, Centella Asiatica Extract, Acetyl Hexapeptide-8, Ceramide NP, Hydrogenated Lecithin, Anthemis Nobilis Flower Oil, Tocopherol, Houttuynia Cordata Extract, Tocopheryl Acetate, Ascorbic Acid Polypeptide, Ammonium Acryloyldimethyltaurate/VP Copolymer, Tromethamine, Carbomer, Octyldodeceth-16, Ethylhexylglycerin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Disodium EDTA, Palmitoyl Tripeptide-5, Pinus Strobus Bark Extract, Hexapeptide-9, Maltodextrin, Lavandula Angustifolia (Lavender) Oil, Linalool

Show All Ingredients +

Depology Peptide Complex Review

This is definitely not the most important feature, but I just wanted to add that I like the packaging. It’s very simple yet very sleek, a little heavy (in a good way), and gives me a luxurious feeling.

As I’m currently 26 years old, I don’t have lots of fine lines and wrinkles yet, but I do have a frowning line on my forehead, and my smile lines are visible. On top of that, starting anti-aging products in your twenties is recommended to prevent further signs of aging.

I do have quite dry skin, so I’m pretty much focused on adding products to my routine that also add moisture. Thankfully, the Depology Peptide Complex 10% Serum formulated with Argireline™ Peptide offers just that in combination with the anti-aging promises!


The formula of the Peptide Complex Serum is transparent, lightweight, and non-greasy. The serum absorbs quite quickly and doesn’t leave a sticky layer on the skin at all.

I started implementing this serum at night time and every other day – as I like to introduce new products slowly. But I think this wasn’t necessary for this serum because I noticed right away that this is a very gentle and non-irritating formula.

Because of it being so gentle, I think lots of people can actually use this Peptide Complex Serum! It doesn’t contain alcohol, which is another pro for people with sensitive skin.

I quickly increased my usage to every night, and I’m currently working my way up to using it in the morning as well. So far, my skin never reacted to the serum in a bad way, such as irritation, breakouts, or redness.

Now, I have the most sensitive, dry, and easily irritated eye area, and just a few days ago, I decided it was time to try the Argireline™ Peptide Serum there, too, and so far, so good! No reaction whatsoever.

Moreover, the serum didn’t react to any other products I already had in my routine. Actually, I could incorporate and combine it with my current products with so much ease. As if I never added another product.


The Depology Argireline™ Peptide Serum has a droplet applicator that works easily and is hygienic. Just add a few drops in your palms and apply them to the specific areas you want. I personally add the serum mainly to my forehead and smile lines.

One of the things that I noticed right after application is that you get instant plumping results. It smooths out fine lines directly – which initially are short-term effects, as it slowly disappears the longer the serum is on the face.

However, if you use this serum consistently, the long-term effects will for sure come as well. I have been using the serum for approx. 3 weeks now, and I can’t say that my fine lines are completely gone, but I do see they’re smoothed out. Especially the fine line I have on my forehead from frowning.


Now, I already told you about the short-term effects that are directly visible after applying the serum – which I think is really nice to see. I don’t think I’ve tried a skincare product that showed me such quick results as this one yet.

However, again, they’re short-term when you’re just starting out with this serum. This is not a bad thing, in my opinion, it’s very promising of the results you’re getting long-term. I’m excited to see how my fine line looks a few weeks from now!

As I have dry skin, I need really hydrating products to make my skin feel replenished and hydrated again. So, to be honest, I didn’t expect that much from the hydrating properties of this serum.

Long story short, I was wrong. The areas where I add the serum are also areas that are often extra dry for some reason (sometimes to the point of being flaky). I noticed that my skin responded well and actually looked less dry after 3 weeks of using this serum.


The Depology Argireline™ Peptide Serum retails for $49, which is pretty average for a skincare serum, I would say, especially if you’re used to products from higher-end brands.

Of course, there are more affordable options (I’m naming one below), so depending on your budget, you can decide what works best for you.

The serum is going to last a decent while, and the benefits short-term and long-term are visible, so I can only say that this serum is worth its price tag.

Who Should Buy The Serum

First of all, I think this serum is perfect for people who are looking to combat fine lines and wrinkles. I also think it’s a great serum for people who are just starting out with anti-aging products (whether this is because you’re young or just a skincare beginner).

I even think that people with sensitive skin will be able to use this gentle serum! So, after all, I’ll work for basically all skin types.

The people who will mostly benefit from this serum are the ones who have dehydrated aging skin and are looking for treatment of the 11’s line area.

Alternatives To Depology Peptide Complex

Even though Depology Argireline™ Peptide Serum is a great option, it is not the only Peptide Complex Serum on the market. Actually, I think the following products have comparable features, so let’s dive in!

Skin Deva Matrixyl+ Argireline Serum

Skin Deva 20% Argireline® + Matrixyl 3000™ + Hyaluronic Acid has several similarities to the Depology Argireline™ Peptide Serum; for example, they’re both cruelty-free, alcohol-free, paraben-free and gluten-free, and they both contain natural ingredients, hyaluronic acid and are made to target fine lines and wrinkles.

The Skin Deva Serum contains Matrixyl 3000™ (which Depology has its own separate serum for) and also focuses on brightening and toning the skin – which the Depology Peptide Complex doesn’t really focus on.

Skin Deva 20% Argireline® + Matrixyl 3000™ + Hyaluronic Acid is lower priced than the Depology Argireline™ Peptide Serum, which may be beneficial for people on a tighter budget.

However, the Depology serum provides research results such as 7.22% reduced wrinkle depth after 28 days and a 45.68% boost of hydration level, which results can’t be found on the Skin Deva site.

Now, onto the actual formulas: The Depology serum absorbs quickly and doesn’t feel sticky or greasy, whereas the Skin Deva serum does feel greasy. You don’t get short-term results from the Skin Deva serum, nor does it hydrate as much as the Depology serum.

Even though I would say that Skin Deva is quite a good option, I would still recommend Depology for the best results.

The Ordinary Argireline Serum

The Ordinary Argireline Serum also contains 10% Argireline, also targets fine lines/signs of aging, and is cruelty-free and alcohol-free, just like the Depology Argireline™ Peptide Serum.

The main ingredient of the Ordinary serum is Acetyl Hexapeptide-8, and it is a water-based formula. On top of that, it is oil-free, gluten-free, silicone-free, and even vegan. And the biggest benefit of them all is the price – The Ordinary is the most affordable option out of them all.

However, The Ordinary Argireline Serum is a very basic serum. It doesn’t provide hydrating benefits like Depology’s serum does, and it takes a long time and true consistency to see any results – if any, results at all.

As The Ordinary serum is water-based, it kind of feels like you’re just applying water to your face. I do like a lightweight serum, but for some reason, this just feels a bit weird. Also, after applying, my skin feels slightly more dry.

The Ordinary would be a great option if you’re on a tight budget and really want to try and battle anti-aging effects. Otherwise, I would pass and invest in a better serum like the Depology serum.

Final Thoughts

The Depology Peptide Complex 10% Serum formulated with Argireline™ Peptide has made a positive impression on my skincare journey. This serum stands out with its impressive 10% peptide complex, delivering promising youth-boosting ingredients.

The formula is transparent, lightweight, and absorbs quickly without leaving a sticky residue. Its gentle nature makes it suitable for a variety of skin types, including sensitive skin.

The application of the serum brings instant plumping results, smoothing out fine lines for short-term effects. With consistent use, it shows potential for long-term benefits in reducing the appearance of fine lines and improving hydration.

The value of the serum is highlighted by its reasonable price tag, especially considering its visible benefits.

  • Lightweight, non-sticky and non-greasy formula
  • Delivers short-term results as well as long-term results
  • Hydrates the skin on top of plumping effects
  • Great for all skin types, even sensitive skin
  • May be expensive for some

The Depology Argireline™ Peptide Serum’s packaging exudes a luxurious feeling, and its formulation, along with its potential for both short-term and long-term results, makes it an attractive addition to anti-aging routines.

While alternatives exist on the market, the Depology serum’s unique combination of peptide technology and hydrating properties positions it as a noteworthy choice for those seeking to combat fine lines and wrinkles.

Ultimately, the Depology Peptide Complex 10% Serum formulated with Argireline™ Peptide emerges as a solid contender for individuals looking to address signs of aging and boost skin hydration, offering visible results and a promising addition to skincare regimens.

Frequently Asked Questions

Yes, you can definitely use Matrixyl and Argireline together in your skincare routine. They actually work quite well when combined.

When you use Matrixyl and Argireline together, they complement each other’s effects and provide a more comprehensive anti-aging approach.

Yes, you can use Argireline™ with niacinamide. These two ingredients work well together and can be incorporated into your skincare routine. If you’re going after those expression line areas, put Peptide Complex 10% Argireline™ Peptide Serum on first. Niacinamide should come after.

Yes, you can use Argireline™ with Tretinoin. However, it is important to start slowly and gradually increase the amount of product that you use. Tretinoin can be irritating to the skin, so it is important to use it with caution.

Yes, but with caution and not simultaneously in your skincare routine. Argireline™ should not be used with direct acids, such as L-ascorbic acid (LAA) or ethylated ascorbic acid (EAA).

Yes, it is safe to use hyaluronic acid with Argireline™. You can use Argireline™ at night to target muscle contractions, while hyaluronic acid can be used in the morning and night to provide hydration and support the skin’s moisture barrier.

Alternatively, you can use both ingredients at the same time of the day, as they have complementary benefits.

shop the post

Leave a Reply

Your email address will not be published. Required fields are marked *